Paradoxically elevated efavirenz concentrations in HIV/tuberculosis-coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy
نویسندگان
چکیده
منابع مشابه
Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.
In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations.
متن کاملImpact of pharmacogenetic markers of CYP2B6, clinical factors, and drug-drug interaction on efavirenz concentrations in HIV/tuberculosis-coinfected patients.
Comprehensive information on the effects of cytochrome P450 2B6 (CYP2B6) polymorphisms, clinical factors, and drug-drug interactions on efavirenz concentrations in HIV/tuberculosis-coinfected (HIV/TB) patients is unavailable. A total of 139 HIV/TB adults, 101 of whom received a rifampin-containing anti-TB regimen, were prospectively enrolled to receive efavirenz (600 mg)/tenofovir/lamivudine. N...
متن کاملEffect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection
OBJECTIVES The main aim of this study was to investigate the effect of CYP2B6 gene polymorphisms on efavirenz (EFV) plasma concentrations in Han Chinese patients with human immunodeficiency virus (HIV) infection. METHODS In total, 322 patients were recruited for study. EFV plasma concentrations at steady-state were determined using high-performance liquid chromatography. Genotyping for seven ...
متن کاملImpact of CYP2B6 and CYP2A6 polymorphisms on efavirenz plasma concentrations in Ghanaian HIV-infected patients
Results The frequency of CYP2B6 516G>T and CYP2A6*9 genotypes were GG 29.8%, GT 44.3%, TT 25.9% and CC 91.6%, AC 8.7%, and AA 0.39%, respectively. Both polymorphisms were statistically associated with efavirenz plasma concentrations. Median plasma concentrations according to CYP2B6 516G>T were 1297, 1833 (P < 0.05) and 2248 (P < 0.001) μg/ml for GG, GT and TT individuals, respectively. Median p...
متن کاملPOPULATION PHARMACOKINETICS OF EFAVIRENZ IN HIV PATIENTS: 1 INFLUENCE OF THE CYP2B6 GENOTYPE 2 3 Running title: INFLUENCE OF CYP2B6 GENOTYPE ON PHARMACOKINETICS
4 Infectious Disease Service. University Hospital of Salamanca, Salamanca, Spain. 14 15 * Correspondence author: 16 Salvador Cabrera Figueroa 17 Servicio de Farmacia. Hospital Universitario de Salamanca 18 Paseo de San Vicente 58 19 37007 Salamanca 20 España 21 Telephone: +34-923291172 22 Fax: +34-923291174 23 [email protected] 24 Copyright © 2009, American Society for Microbiology and/or ...
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ژورنال
عنوان ژورنال: AIDS
سال: 2011
ISSN: 0269-9370
DOI: 10.1097/qad.0b013e3283427e05